Meet the Busby Family, which includes mom Danielle, dad Adam, 4-year old daughter Blayke, and 5 baby girls. 40 bottles a day, 420 diapers a week and feedings every 3 hours became the new normal for Danielle & Adam when they welcomed home the only all-female set of quintuplets.

Matt & Amy Roloff enlist the help of their four children Jeremy, Zack, Molly & Jacob to help expand the business of Roloff farms. As the kids grow older, the family grows larger and the Roloffs learn how to keep their family relationships strong.

Karen and Deon Derrico are parents to four sets of multiples -- 14 kids, including a set of quintuplets -- conceived NATURALLY! The birth of their triplets brings the couple new challenges that will test everything they know about parenthood.

The Johnstons are an average American family of seven except everyone is a little person. Distinguished from others as they only depend on each other to prove size doesn't matter. They juggle family and health issues in the middle of a home renovation.

Courtney and Eric Waldrop were High School sweethearts from Albertville, Alabama who already have a young son and two twin boys. But now that mom is pregnant with sextuplets their entire life is about to be turned upside down.

The nine flaxen-haired children in the Plath family have never had a soda, don't know who Spiderman or Tom Brady is and have never watched TV, living remotely in rural Georgia with their "follow their own rules" parents Kim and Barry Plath.

For Dr. Mercy Odueyungbo, dermatology isn't just skin deep. In her Chicago practice, she specializes in treating the most unusual, extreme and rare skin disorders, while also helping patients regain a sense of confidence and self-worth.

Americans move to a foreign country all in the name of love. Will uprooting their lives in the United States pay off, or will they be packing up and moving back to America brokenhearted?

Karen and Deon Derrico are parents to four sets of multiples -- 14 kids, including a set of quintuplets -- conceived NATURALLY! The birth of their triplets brings the couple new challenges that will test everything they know about parenthood.

Ever since Chantel first introduced Pedro to her family under the false pretense of him coming to America on a student visa, the drama that followed has kept fans obsessed. Viewers will follow this unique modern family as they try to move past their differences and come together.

At first glance, the Browns are a typical big American family, but as patriarch Kody explains; “I fell in love, fell in love again, and then again, and then again.” This is a look at the polygamist lifestyle of Kody Brown, his 4 wives, and their extraordinary family.

The Slaton's are larger-than-life sisters who have always relied on each other and food for support. Amy, age 31, is desperate to have children, but hasn't been able to due to her weight. While Tammy, age 32, is one step away from being bedridden.

In this digital series, delve into the lives of the 90 Day Fiancé couples that we never got to see past their “I do’s."

Catch up with your favorite mothers and daughters from the TLC hit show, sMothered, and meet the new duos that take the phrase "like mother, like daughter" to the extreme!

See more hair and nail transformations from the Martones!

In an all new six-part TLCgo original series, three Americans prepare as each of their fiancés is about to arrive from overseas. Once those planes land, the most critical 24 hours of their relationships begin.

Dr. Sandra Lee shares all the gory details behind some of her most difficult pops. Watch intimate excavation videos of blackheads so big and cysts so goopy, they have to be seen to be believed.