Meet the Busby Family, which includes mom Danielle, dad Adam, 4-year old daughter Blayke, and 5 baby girls. 40 bottles a day, 420 diapers a week and feedings every 3 hours became the new normal for Danielle & Adam when they welcomed home the only all-female set of quintuplets.

Matt & Amy Roloff enlist the help of their four children Jeremy, Zack, Molly & Jacob to help expand the business of Roloff farms. As the kids grow older, the family grows larger and the Roloffs learn how to keep their family relationships strong.

Karen and Deon Derrico are parents to four sets of multiples -- 14 kids, including a set of quintuplets -- conceived NATURALLY! The birth of their triplets brings the couple new challenges that will test everything they know about parenthood.

The Johnstons are an average American family of seven except everyone is a little person. Distinguished from others as they only depend on each other to prove size doesn't matter. They juggle family and health issues in the middle of a home renovation.

Courtney and Eric Waldrop were High School sweethearts from Albertville, Alabama who already have a young son and two twin boys. But now that mom is pregnant with sextuplets their entire life is about to be turned upside down.

The nine flaxen-haired children in the Plath family have never had a soda, don't know who Spiderman or Tom Brady is and have never watched TV, living remotely in rural Georgia with their "follow their own rules" parents Kim and Barry Plath.

In this digital series, delve into the lives of the 90 Day Fiancé couples that we never got to see past their “I do’s."

Catch up with your favorite mothers and daughters from the TLC hit show, sMothered, and meet the new duos that take the phrase "like mother, like daughter" to the extreme!

See more hair and nail transformations from the Martones!

Dr. Sandra Lee shares all the gory details behind some of her most difficult pops. Watch intimate excavation videos of blackheads so big and cysts so goopy, they have to be seen to be believed.

The Slaton's are larger-than-life sisters who have always relied on each other and food for support. Amy, age 31, is desperate to have children, but hasn't been able to due to her weight. While Tammy, age 32, is one step away from being bedridden.

At first glance, the Browns are a typical big American family, but as patriarch Kody explains; “I fell in love, fell in love again, and then again, and then again.” This is a look at the polygamist lifestyle of Kody Brown, his 4 wives, and their extraordinary family.

Follow participants as we document the life-saving, but traumatic experience of surgery, the ups and downs of struggling with addiction and dependence, and the inevitable impact that change has on personal relationships.

Meet the Busby Family, which includes mom Danielle, dad Adam, 4-year old daughter Blayke, and 5 baby girls. 40 bottles a day, 420 diapers a week and feedings every 3 hours became the new normal for Danielle & Adam when they welcomed home the only all-female set of quintuplets.

Dancing her way through the haters, Whitney Thore is embracing her body in a world that judges people by their size. After being diagnosed with PCOS and the success of her “fat girl” dancing videos, Whitney’s choosing to live vivaciously and holding nothing back.

From the most extravagant wedding gowns to explosive celebrations and the madness that follows, My Big Fat American Gypsy Wedding delves into the lives of America's most elusive communities - the world of Romanichel and Roma gypsies.

Check in on the men and women featured in “My 600lb Life.” Since the show, have they maintained their weight loss and continued working toward their goals? We get an update on where they are now and what’s changed since the show.

The Martones are a loud, fun-loving Italian family from Long Island. Sisters Lexi, a talented nail artist, and Bria, a hair colorist/makeup artist, run Salon Martone while juggling family dynamics, over the top clients, and their own relationships.

The Johnstons are an average American family of seven except everyone is a little person. Distinguished from others as they only depend on each other to prove size doesn't matter. They juggle family and health issues in the middle of a home renovation.

We get a look at the final weeks of pregnancy for three teen couples and the first few months of parenthood with teens who happened to have been raised by teens.

Patients of Dr. Brad Schaeffer and Dr. Ebonie Vincent undergo surgery to have their feet radically transformed and their lives changed forever.

Dr. Sandra Lee isn’t just one of America’s top dermatologists; she’s an Instagram and YouTube celebrity who has pioneered the fastest growing medical fascination in decades.