650-lb Melissa struggles to get to her ideal weight.

Love motivates 660-lb Donald to begin his weight loss journey.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Ashley's career was derailed after she was let go due to her excessive weight. Will she be able to turn her life around and achieve her goal of owning a childcare facility?

During her second year of weight-loss, Zsalynn is torn between fighting her weight and fighting for her marriage. Christina lets go of the negative influences in her life and is finally able to live the life of a twenty-something.

Olivia strives to weigh-in under 200-lbs as she lives by herself for the first time & suffers an unexpected loss. Battling a series of let downs, James fights to reach his goal of skin surgery and to live a fulfilling relationship for the first time.

Away from Dr. Nowzaradan’s care, Penny has returned to Maryland believing she can make the choices to lose weight, but has she truly changed? Dating for the first time in her life, Tara continues to lose weight and is learning to balance new roles.

Chuck starts from scratch during his second year of weight-loss, discovering a promising new relationship. Paula juggles many responsibilities head at once, but is it too much to stay on track for her weight-loss goal?

Melissa finds herself overwhelmed with four children, a marriage on the rocks, and an unexpected pregnancy. When Ashley’s weight loss journey hits a wall, she sets out to find new inspiration to get herself back on track towards a healthy lifestyle.

Christina's weight loss has gone too far, too fast, and now threatens her life. After losing 300lbs, Paula must endure more surgery to deal with a body entirely covered in loose and sagging excess skin.

Zsalynn is excited for a fresh start but her 360-body lift at a Beverly Hills clinic proves more challenging than expected. Lonely and depressed since her gastric surgery, Olivia wants skin removal surgery but struggles to lose the weight to qualify.

Bettie Jo battles depression and a cancer diagnosis and when she finds out she's pregnant, she and her husband must find a way to cope. Susan suffers a major setback after surgery for her excess skin, thwarting her hopes to conquer her obesity.

Joe has come a long way from being morbidly obese...He's in love & contemplating proposing to his girlfriend. Just when life holds so much promise, his mom has a few health scares & forces Joe to balance his new love with his mother's health crisis.

Despite having lost 378lbs, Angela's knee pain combined with a history of obesity threatens everything she's worked for. Charity must find the strength to return to her goals of getting healthy.

Laura has lost 300lbs+ and is much less dependent on her husband Joey, who is now having trouble finding his way in the relationship. Marla, one of Dr. Now's most challenging patients returns and the fireworks begin all over again.

Pauline must find the will to keep up her weight-loss progress after a medical emergency. Chay's finally admitting what he's long known, that he's a transgender woman. But, the emotional stress of coming out could threaten his weight loss journey.