650-lb Melissa struggles to get to her ideal weight.

Love motivates 660-lb Donald to begin his weight loss journey.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Ashley's career was derailed after she was let go due to her excessive weight. Will she be able to turn her life around and achieve her goal of owning a childcare facility?

After meeting and falling in love at a bariatric rehab center, Lee and Rena are battling health and anger issues while taking a desperate, second attempt to save their relationship and their lives.

Janine's extreme obesity has left her nearly immobile, and even the first steps on her weight loss journey may prove to be too much for her. She must overcome both her physical and emotional pain if she's ever going to live a normal life again.

A devoted girlfriend and loving aunt, Alicia is all smiles and laughter on the outside, but on the inside she is terrified that her addiction to food will kill her before she can marry her long-time love or watch her nieces grow up.

Liz is completely bed bound with severe lymphedema that makes it impossible to walk. Utterly isolated, with no friends, she battles depression, and lives with her mom who is too ill to take care of her. Liz desperately wants to become mobile.

Unable to stand for more than a short period of time, Karina's weight has placed a burden on her parents and driven a wedge between she and her sister. Can Karina lose weight and repair the damage to her family?

Lisa's struggle with her weight began as a child and significantly worsened after witnessing her brother's murder. Now bedridden and unable to care for herself, Lisa must find a way to lose the weight or she will never see her grandchildren grow up.

With the support of his fiance, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life. He tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.

After years of a tumultuous relationship with her husband, Tamy's eating addiction has caused her weight to balloon over 500-lbs. She has become a hermit after years of shame, and hopes to restart her life so she can better care for her son Zachary.

Fearing that he'll suffer the same fate as older brother David, who is now 700-lbs and unable to work, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

A former plus-size model and "big is beautiful" advocate, Renee now realizes the mortal mistakes she has made as her weight swells to 600-lbs and her health crumbles.

After a difficult childhood with an abusive stepfather and drug-addicted mother, Sarah weighs over 600-lbs and is fighting for her life at only 24 years old.

Devastated by two miscarriages due to her weight, Schenee is desperate to start a family and stop relying on her husband, Freddie, to take care of her. Will weight loss surgery be able to fix her fertility issues as well as her marriage?