650-lb Melissa struggles to get to her ideal weight.

Love motivates 660-lb Donald to begin his weight loss journey.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Ashley's career was derailed after she was let go due to her excessive weight. Will she be able to turn her life around and achieve her goal of owning a childcare facility?

Twins Kandi & Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losing each other to obesity, so they make a change together. But a life-threatening event during weight loss surgery recovery may separate them forever.

At 670 pounds Ashley must live in her parents' home with her husband. Desperate to save her life and her marriage, she decides it's time for a drastic change. Can weight loss surgery save her life?

Cynthia is a 610-lb single mother raising five kids. She's been focused on her children, but now realizes what her death would mean for them. As she battles her emotions & the pressures of life, she is forced to fight harder to save her own life.

Weighing over 600-lbs Kirsten is close to losing her mobility. While she's trying to get control of her obesity she's also in danger of losing her troubled son. She must regain her health in order to be the best mother she can to care for her son.

After overcoming a dependence on drugs & alcohol, sneaking food is 660-lb Doug's last remaining vice. Can this husband, and father of 3 overcome his addictive personality and take control of his eating habits in order to save his life & his marriage?

At 661 lbs, Erica regrets not keeping a promise to her mom. She hopes her siblings will help but they are reluctant based on past failures. Each meal threatens Erica's worst fear coming true; dying the same way she lives, alone & surrounded by food.

Diana, a once thin & active woman, is now a prisoner to her 620lb body. Desperate to break free of her food addiction, she trades the comfort of her home for a weight loss journey under the strict authority of her niece in order to regain her life.

Michael's massive 632lb body has left him completely dependent upon his family. If he doesn't learn to control his anger issues around food, lose weight, and address the root of his issues, then he will remain in jeopardy of losing everything.

Weighing over 700-lbs, Nicole is on the verge of leaving her two young children motherless. Trying to survive a family of addicts, she commits to Dr Nowzaradan's diet program, but crisis threatens to derail all her hopes for weight-loss.

Tanisha weighs around 600-lbs and she's desperate to survive for her kids and avoid her mother's tragic fate of dying at age 50 from super obesity. Now at 32, her future looks grim if she doesn't make a drastic change to save her life.

Weighing 791-lbs, James is bedridden, unable to stand, and can barely move his legs. He may only have a few months to live, so his family takes a high-risk journey to Houston, TX with the hope that bypass surgery can save his life.

Most of the extreme weight on Tracey's body resides in her shockingly misshapen legs. They're so massive with severe lymphedema, that gastric surgery is her only chance of survival. Will this mother & grandmother ever gain control of her overeating?