650-lb Melissa struggles to get to her ideal weight.

Love motivates 660-lb Donald to begin his weight loss journey.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Ashley's career was derailed after she was let go due to her excessive weight. Will she be able to turn her life around and achieve her goal of owning a childcare facility?

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life and faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

Robin and her brother Chris are both obese and have lost a sibling to obesity. They plan to visit Dr. Now together when Chris suffers a stroke and can't go. However, Chris's son Garrett, already 600-lbs at age 20, may join the journey with his aunt.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food. Now only the help of Dr. Now's weight-loss program can restore his hope of living a happy, productive life.

Holly already has one failed weight loss surgery, so to succeed this time, she must do more than change her eating habits, she must address the childhood issues that continue to plague her.

Lacey ballooned up over 600 lbs on pizza and ice cream and knows Dr. Now is her best hope for success. She must now rally her divorced parents around her for support and find a way to modulate her moods that won't include binge-eating.

Brandon is a talented musician with a beautiful voice and a run-away weight problem. He wants more than to lose weight, he wants a career and he wants to take the next step with his girlfriend Taylor whom he risks losing if he can't make a change.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend Christian. But when Christian decides he's had enough and leaves Maja high & dry, she will discover that the only person she can count on is herself.

Despite moving to Houston with the solid support network of her boyfriend Aaron & her cousin Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Born as 'Matthew', Destinee never felt like she fit in. Now, having come out as a 600 pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father. At well-over 600 lbs., Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Since the death of his mother, Aaron has lived at home to care for his aging father. But due to his food addiction, Aaron has to heavily rely on his father for help instead. Now, Aaron must learn to care for himself to avoid eating himself to death.