650-lb Melissa struggles to get to her ideal weight.

Love motivates 660-lb Donald to begin his weight loss journey.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Ashley's career was derailed after she was let go due to her excessive weight. Will she be able to turn her life around and achieve her goal of owning a childcare facility?

Zsaylnn, once known as the "Fat Girl Rock Star" - married a man who loves large women. Now weighing over 600lbs, she urgently needs to lose weight to be the mother her daughter deserves. Can she succeed with a husband who doesn’t support her goals?

Battling severe depression in the wake of a suicide attempt, 46-year old Olivia hasn't left her Chicago basement in two years. With one last chance at a new life, Olivia will travel to Houston with the hope of having a life-changing surgery.

Bedridden for four years, 46-year old Penny knows that her weight may kill her if drastic actions aren’t taken. Penny moves from Maryland to Texas, to have gastric bypass - but her unwillingness to make real lifestyle changes could be her downfall.

Chuck weighs almost 700lbs & it has hindered every aspect of his life. He’s had to downsize his business and his wife feels like a single-parent, who is ready to leave him. Can Chuck reclaim the life that’s slipping through his fingers?

Christina is a 22-year old married woman from South Haven, Mississippi, who hasn’t left her house in 2 years due to her size. Her doting family has enabled her & she’s eaten herself into a state that will soon kill her, if she can’t make a change.

Paula has had a tough life, & at over 600lbs, has built a physical wall around herself to push people away. When she suddenly loses someone she loves, Paula can no longer ignore the threat of losing her own life - especially for her children’s sake.

James comes from a long line of family obesity & at 706lbs, is determined not to die in the same hospital bed that his father & sister did. James vows to change his lifestyle in order to get gastric bypass & even has long-term hopes of dating again

Tara is a mother of 2 from Lafayette, LA. Addicted to food, she is too ashamed of her size to be seen with her kids, confining herself indoors. Seeking gastric bypass, Tara is committed to regaining her confidence & being a proud mother once more.

At age 23, and over 600-lbs, Amber relies on her family, and boyfriend for even simple needs. Her fear of dying young is so overwhelming that she makes the decision to relocate 2,000 miles in hopes that weight loss surgery will give her life back.

Weighing in at over 600-lbs, 37 year old Susan is committed to drastic weight loss. But, when an unforeseen medical disorder strikes her mobility, finding the strength to make it through these obstacles is a matter of life and death. 

At nearly 700 lbs., 51-year-old Pauline has an addiction to food that is killing her and taken over the life of her son, who is the primary caretaker. Can she overcome this addiction to change her lifestyle and save both their lives? 

At just 24, Bettie Jo is eating her way towards 700-lbs. Housebound, she is reliant on her husband for even basic needs. Bettie Jo's future relies on her losing weight, and her husband losing his fear that if she loses weight, she will leave him.