650-lb Melissa struggles to get to her ideal weight.

Love motivates 660-lb Donald to begin his weight loss journey.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Ashley's career was derailed after she was let go due to her excessive weight. Will she be able to turn her life around and achieve her goal of owning a childcare facility?

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

Dr. Nowzaradan is worried Lupe's emotional issues are blocking her weight loss journey since she's shed over 300-lbs but still can't walk... And when Ashley is struck with sudden paralysis, her own emotional stability is thrown into peril.

Gastric surgery freed Brittani from her housebound life, but to achieve her ideal body she'll have to endure two more painful surgeries. Sean's super-obesity nearly killed him...Will he finally make a break from his mother's over-protective care?

Surgery enables Teretha to finally return to family in Detroit but it soon threatens to undo all the progress she's made. After his weight loss surgery, trucker Chad gets back on the road, but the job is putting any further weight loss in peril.

After losing 250lbs, Nikki is on her way to skin surgery that will transform her body. But when a close friend dies from weight loss surgery, Nikki's progress goes off track, derailed by fears of another surgery and if she'll make it out alive.

Devastated by the sudden loss of her son, Dottie's weight loss journey is in danger of going off track. After her gastric bypass surgery, June embarks on a plan to win approval for skin surgery and start living the life she always dreamed of having.

Charity managed to lose over 400 pounds, but now her daughter Charly is becoming dangerously obese. Can Charity help her avoid the same fate? Devastated by the death of her husband Elroy, Milla must find a way to finally qualify for gastric bypass.

Joe was once 800lbs, housebound and alone. Now engaged and planning a wedding, can he continue his weight loss? After losing over 300lbs, Pauline is on the verge of independence if only she can qualify for the skin surgery she needs so badly.

Surgery enabled Laura's independence but the complications nearly killed her and she's terrified about the skin surgery. Chay revealed to her family she was transgender but living life as an overweight woman; can she stick to her weight loss journey?

Steven Assanti's dysfunction escalates, pushing his relationship with Dr. Nowzaradan to the brink, and a risky decision is made to save Steven's life, while brother Justin takes the leap to go to Houston to finally accept help.

At 400lbs Bettie Jo achieves a dream - she's pregnant. But the pregnancy is soon in jeopardy. Will she deliver baby without complications? Susan lost 400lbs and she's in a relationship. When weight loss stalls, can she turn things around again?

11 years later, Melissa has lost 500lbs and saw her weight drop to 137lbs. Now facing marital problems, three pregnancies, and life as a single mom, Melissa is struggling with a 150lb weight gain. Melissa is at a crossroads; can she find her way?