Brandon is a talented musician with a beautiful voice and a run-away weight problem. He wants more than to lose weight, he wants a career and he wants to take the next step with his girlfriend Taylor whom he risks losing if he can't make a change.

Maja moves to Houston to undertake a difficult weight-loss journey with the support of her boyfriend Christian. But when Christian decides he's had enough and leaves Maja high & dry, she will discover that the only person she can count on is herself.

Despite moving to Houston with the solid support network of her boyfriend Aaron & her cousin Jasmine, Tiffany finds it difficult to break the cycle of depressed eating when her two roommates don't join her diet and leave the house every day for work.

Born as 'Matthew', Destinee never felt like she fit in. Now, having come out as a 600 pound transgender woman, she likes her curves, but she will need to say goodbye to them if she wants to be approved to transition completely.

Jeanne lives in an unhygienic household with her mother and schizophrenic father. At well-over 600 lbs., Jeanne might never get weight-loss surgery as she runs into several obstacles, especially after an unexpected death in her family.

Since the death of his mother, Aaron has lived at home to care for his aging father. But due to his food addiction, Aaron has to heavily rely on his father for help instead. Now, Aaron must learn to care for himself to avoid eating himself to death.

Kelly is on the verge of immobility when she decides to make the trip to Houston to visit Dr. Now. Her journey gets off to a painful start when a long travel-day grows longer as Kelly gets stuck in a cab on her way from the clinic to the hospital.

When Annjeanette was 9, a campaign was established to send her to fat camp. She hated that her weight had become a source of public shame and she has struggled to overcome her food addiction. Now, she must change her habits to save her life.

When Angela's family is unable to accompany her on her weight-loss journey to Texas she is unsure what to do. At the last minute, she reaches out to an old flame, Eric, who still has love for her and is willing to make the trip.

Bed-bound for 2 years, Lashanta relies on her 4 kids to keep her cleaned and fed. Her last chance to break the cycle of food addiction that's killing her is to join Dr. Now's program, but it will take a village just to get her out the door.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her 3 daughters. If he doesn't lose weight soon, he knows he'll lose either his girls, or his life.

With severe lymphedema, Mercedes can barely stand and cares for her 2 small children with the help of her extended family. Dr. Now can give her the tools to lose weight, but to succeed she must face the trauma inflicted by her late abusive father.

At over 600 pounds, Angie is trying to get to Houston to see Dr. Nowzaradan, in hope of getting life-saving weight loss surgery. But family conflict and a disagreement may stop her from being able to do what she needs before she even gets the chance.

Weighing over 600 lbs. each, Vianey and Allen are locked in a codependent relationship based on a shared love of food. As they head to Houston, they will soon find out if their relationship can handle the strain of growing healthy together.

John & Lonnie are two brothers from opposite ends of the spectrum. For years estranged, the brothers are now brought together by a common need to lose weight while they still can.

Bethany has two daughters who live in fear of losing their mom to her food addiction. Once an addiction counselor, Bethany has gotten so big that she can no longer work. Now she risks losing her life, if Dr. Now can't help her curb her own addiction.