The lives of obese cousins Naomi, Drew and Chitoka are in danger.

Drew wants to have the weight loss surgery, and Chitoka asks for help.

Chitoka tries to become more mobile, starting by leaving her bedroom.

Two people undergo surgery to remove excess skin left after weight loss.

Two women undergo surgery to remove excess skin from extreme weight loss.

Two people have surgery to remove skin remaining after major weight loss.

At 650 lbs, Melissa is ready to begin her seven-year weight loss journey.

Two years after her surgery, Melissa struggles to get to her ideal weight.

Motivated by love, 675-lb Donald begins his weight loss journey.

At 715 lbs, Henry hopes to transform himself and attend his school reunion.

Ashley aims to turn her life around after being let go due to her weight.

At nearly 1,000 pounds, Samantha is dangerously close to dying.

Whitney's determined to show the world she can still dance at 380 pounds.

Hateful jeers could derail the success of Whitney's dance class.

Whitney's new "Say-Yes" philosophy lands her in a plus-size fashion show.

Whitney confesses a secret love and faces a tough decision.