Adam and Danielle Busby defy all odds by giving birth to the first set of all girl quintuplets in the US. After four months in the NICU, the quints come home and along with four-year-old sister Blayke, turn Adam and Danielle's lives upside down.

Adam and Danielle struggle to keep up with the demands of the quintuplets while also making time for 4-year-old daughter, Blayke. Later, a baby photo shoot with the quints turns into pure chaos when Grandma Mimi shows up late to help.

Adam returns to work, leaving Danielle to care for the quintuplets and Blayke by herself for the first time. On Adam's first day back, Hazel falls ill with a fever, leaving the family scrambling and Danielle feeling overwhelmed and alone.

Adam & Danielle realize they need a larger home, but house hunting proves stressful when they realize what a larger house will cost. Later, the family heads back to their hometown & Danielle comes up with an idea that could solve all their problems.

The Busbys are back & life is more chaotic than ever! Adam & Danielle have their hands full chasing after their 15 month old quints. And when a doctor recommends an extreme medical procedure for one of the girls, the Busbys face a difficult decision.

The Busbys take a road trip to Lake Charles to help Mimi with her garage sale, and Danielle learns some shocking news from her mom. Meanwhile Danielle & Adam wrestle with a difficult decision of whether or not to allow Hazel to have eye surgery.

When Hazel undergoes eye surgery, Adam and Danielle must anxiously wait to find out if it was a success. Meanwhile at home, life is chaotic as usual as Blayke prepares for kindergarten and Mimi officially moves in.

When Danielle catches the flu, Mimi struggles to take care of 5 babies on her own. Adam plans a 10-year anniversary surprise for Danielle. Later, when Danielle gives a speech for the hospital, she faces the painful past of having premature babies.

Danielle and Adam explore sending the quints to nursery school, but when one of the them isn't allowed to go, the Busbys face the difficult decision of splitting the girls up. As for Mimi, living under the Busby roof has begun to take a serious toll.

After Danielle confronts Adam about his money spending ways, they realize they need to make some tough choices to provide for their six girls. They also continue to step up their efforts to get Hazel walking so she can join her sisters in pre-school.

It's Halloween, but before the Busbys can celebrate the Quints' first trick-or-treat outing, they have to find costumes, shop for pumpkins and get the new house ready for a Halloween party, all while making a final decision on a $100,000 investment.

It's the quints' first family vacation! But with five toddlers running wild, it may feel more like work than vacation time for Adam and Danielle. Meanwhile, Adam struggles to tell his brother-in-law, and boss, about the new business he's starting.

It's Thanksgiving at the Busby household! Adam & Danielle decide to host 20 people but soon realize they have bitten off more than they can chew. Meanwhile, Hazel has a major breakthrough and Adam & Danielle push Mimi to consider apartment living.

When a talk show asks the Busbys to make a live TV appearance in New York, the family heads to the Big Apple. But traveling with 6 kids is as difficult as it sounds! And a last-minute trip to the doctor has Danielle and Adam concerned about Hazel.

With the quints hitting the 'terrible twos' the Busbys are busier than ever! Danielle plans a romantic Valentine's Day dinner for Adam, but things don't go as planned. Adam and Danielle prepare themselves for Hazel's upcoming eye appointment.

With the possibility of another surgery looming for Hazel, Adam stresses over her upcoming appointment with a new doctor. And when the quints start having poop explosions, Daniel attempts potty training to disastrous results.