Cousins Naomi, Drew, and Chitoka are morbidly obese. They are eating themselves to death & without weight loss surgery their lives could be cut short. Family matriarch Beverly has surgery in part to inspire the others to do the same. Can they do it?

The Quinn-Davises are a blended family divided against itself. The kids are acting out and the parents are on the cusp of divorce. Jo whips them into shape but when a child ends up in the hospital and another gets devastating news, will Jo be enough?

The Mead family is in complete chaos, with constant screaming and yelling. The children are really feeling the effects and what is worse, Mom and Dad have a secret that is tearing them apart. Can Jo help them let go of the past and restore trust?

With an impatient dad, a mom who feels like a single parent and a son in trouble with the law, the Campos family is in distress. Mom will leave dad if he can’t step up and Jo must force him to see the consequences of his actions on the entire family.

Kay and Mitch's kids are out of control, lashing out in physical fights. The real issue is their relationship; Kay is the disciplinarian and Mitch acts more like one of the kids than a dad. Can Jo convince this family that change truly is possible?

Debbie and Larry have three adopted girls who are unruly and disrespectful. Mom doesn't believe in consequences. Dad feels the girls need boundaries but there are sensitivities regarding the adoption. Can Jo tackle the issue and instill discipline?

Crystale has a list of issues with her family. She can’t forgive her long-time boyfriend for cheating, accept her daughter's sexuality or be affectionate to her sons. Everyone’s on edge. Can Jo get through to Crystale and bring this family together?

650-lb Melissa begins her seven-year weight loss journey.

650-lb Melissa struggles to get to her ideal weight.

Love motivates 660-lb Donald to begin his weight loss journey.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Ashley's career was derailed after she was let go due to her excessive weight. Will she be able to turn her life around and achieve her goal of owning a childcare facility?

Octavia has been bedbound for nearly a year when she decides to make the trip to Houston to get help from Dr. Now, but when it turns out that her best friend is also her worst enabler, Octavia will have to choose between old habits and a new life.

At over 700 pounds, Brianne undertakes a weight-loss journey to save her own life and faces an unexpected challenge to her fragile progress when her husband suffers a heart attack on a birthday she will never forget.

Robin and her brother Chris are both obese and have lost a sibling to obesity. They plan to visit Dr. Now together when Chris suffers a stroke and can't go. However, Chris's son Garrett, already 600-lbs at age 20, may join the journey with his aunt.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food. Now only the help of Dr. Now's weight-loss program can restore his hope of living a happy, productive life.