While recovering from COVID-19, Tammy's weight spirals.

Sisters Amy and Tammy must lose weight to qualify for bariatric surgery.

With her weight spiraling, Tammy makes a life-altering decision.

Amy and Tammy Slaton are back to share their lives and weight struggles. 1000-lb Sisters returns November 15 at 10/9C.

At 650 lbs, Melissa is ready to begin her seven-year weight loss journey.

Two years after her surgery, Melissa struggles to get to her ideal weight.

Motivated by love, 675-lb Donald begins his weight loss journey.

At 715 lbs, Henry hopes to transform himself and attend his school reunion.

Ashley aims to turn her life around after being let go due to her weight.

Zsaylnn pursues weight-loss surgery in hopes of being a better mother.

Olivia attempts a life-changing surgery to turn her life around.

Bedridden for years, Penny moves to Texas for weight-loss surgery.

At almost 700 pounds, Chuck faces the loss of his business and marriage.

A young, married woman hopes weight-loss surgery will change her life.

Paula, over 500 pounds, pursues weight-loss surgery to change her life.

James, over 700 pounds, pursues weight-loss surgery.